诱导细胞衰老：使神经退行性疾病在体外发生。
Inducing cellular aging: enabling neurodegeneration-in-a-dish.
机构信息
Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.
出版信息
Cell Stem Cell. 2013 Dec 5;13(6):635-6. doi: 10.1016/j.stem.2013.11.017.
Abstract
The immaturity of neurons differentiated from human induced pluripotent stem cells (hiPSCs) presents difficulties for modeling late-onset neurodegenerative disorders such as Parkinson's disease. Now, Miller et al. (2013) provide a strategy for inducing aging-related phenotypes in hiPSC-derived neurons, enabling in vitro study of late-onset neurodegenerative diseases.
摘要
由人诱导多能干细胞（hiPSC）分化而来的神经元不成熟，这给模拟帕金森病等迟发性神经退行性疾病带来了困难。现在，Miller 等人（2013）提供了一种在 hiPSC 衍生神经元中诱导与衰老相关表型的策略，使迟发性神经退行性疾病的体外研究成为可能。
相似文献
1
Inducing cellular aging: enabling neurodegeneration-in-a-dish.诱导细胞衰老：使神经退行性疾病在体外发生。
Cell Stem Cell. 2013 Dec 5;13(6):635-6. doi: 10.1016/j.stem.2013.11.017.
2
Human iPSC-based modeling of late-onset disease via progerin-induced aging.基于人诱导多能干细胞的早衰症模型通过早衰素诱导衰老。
Cell Stem Cell. 2013 Dec 5;13(6):691-705. doi: 10.1016/j.stem.2013.11.006.
3
Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome.源自哈钦森-吉尔福德早衰综合征的 iPS 细胞再现早衰。
Nature. 2011 Apr 14;472(7342):221-5. doi: 10.1038/nature09879. Epub 2011 Feb 23.
4
Generating Late-Onset Human iPSC-Based Disease Models by Inducing Neuronal Age-Related Phenotypes through Telomerase Manipulation.通过端粒酶操作诱导神经元衰老相关表型来生成基于人诱导多能干细胞的迟发性疾病模型。
Cell Rep. 2016 Oct 18;17(4):1184-1192. doi: 10.1016/j.celrep.2016.09.062.
5
Aged induced pluripotent stem cell (iPSCs) as a new cellular model for studying premature aging.衰老诱导多能干细胞（iPSCs）作为研究早衰的新型细胞模型。
Aging (Albany NY). 2017 May 31;9(5):1453-1469. doi: 10.18632/aging.101248.
6
Aging in a Dish: iPSC-Derived and Directly Induced Neurons for Studying Brain Aging and Age-Related Neurodegenerative Diseases.在培养皿中衰老：iPSC 衍生和直接诱导神经元用于研究大脑衰老和与年龄相关的神经退行性疾病。
Annu Rev Genet. 2018 Nov 23;52:271-293. doi: 10.1146/annurev-genet-120417-031534. Epub 2018 Sep 12.
7
Induced pluripotent stem cells reveal functional differences between drugs currently investigated in patients with hutchinson-gilford progeria syndrome.诱导多能干细胞揭示了目前在亨廷顿病戈谢病综合征患者中研究的药物之间的功能差异。
Stem Cells Transl Med. 2014 Apr;3(4):510-9. doi: 10.5966/sctm.2013-0168. Epub 2014 Mar 5.
8
Reprogramming of HUVECs into induced pluripotent stem cells (HiPSCs), generation and characterization of HiPSC-derived neurons and astrocytes.将人脐静脉内皮细胞（HUVECs）重编程为诱导多能干细胞（HiPSCs），HiPSC来源的神经元和星形胶质细胞的生成及特性研究。
PLoS One. 2015 Mar 19;10(3):e0119617. doi: 10.1371/journal.pone.0119617. eCollection 2015.
9
Embryonic senescence and laminopathies in a progeroid zebrafish model.早衰斑马鱼模型中的胚胎衰老和核纤层蛋白病。
PLoS One. 2011 Mar 30;6(3):e17688. doi: 10.1371/journal.pone.0017688.
10
Application of human induced pluripotent stem cells for modeling and treating neurodegenerative diseases.人诱导多能干细胞在神经退行性疾病建模和治疗中的应用。
N Biotechnol. 2015 Jan 25;32(1):212-28. doi: 10.1016/j.nbt.2014.05.001. Epub 2014 May 9.
引用本文的文献
1
Microfluidic models of the neurovascular unit: a translational view.神经血管单元的微流控模型：转化视角。
Fluids Barriers CNS. 2023 Nov 27;20(1):86. doi: 10.1186/s12987-023-00490-9.
2
Progress and challenges in directing the differentiation of human iPSCs into spinal motor neurons.将人类诱导多能干细胞定向分化为脊髓运动神经元的研究进展与挑战
Front Cell Dev Biol. 2023 Jan 5;10:1089970. doi: 10.3389/fcell.2022.1089970. eCollection 2022.
3
Accelerated neuronal aging ∼melting watch ∼.加速的神经元衰老 ∼ 融化的手表 ∼
Front Aging Neurosci. 2022 Aug 9;14:868770. doi: 10.3389/fnagi.2022.868770. eCollection 2022.
4
The iNs and Outs of Direct Reprogramming to Induced Neurons.直接重编程为诱导神经元的来龙去脉
Front Genome Ed. 2020 Sep 4;2:7. doi: 10.3389/fgeed.2020.00007. eCollection 2020.
5
Reconstitution of the Human Nigro-striatal Pathway on-a-Chip Reveals OPA1-Dependent Mitochondrial Defects and Loss of Dopaminergic Synapses.人黑质纹状体通路芯片重建揭示 OPA1 依赖性线粒体缺陷和多巴胺能突触丢失。
Cell Rep. 2019 Dec 24;29(13):4646-4656.e4. doi: 10.1016/j.celrep.2019.11.111.
6
Utilizing induced pluripotent stem cells (iPSCs) to understand the actions of estrogens in human neurons.利用诱导多能干细胞（iPSC）来了解雌激素在人类神经元中的作用。
Horm Behav. 2015 Aug;74:228-42. doi: 10.1016/j.yhbeh.2015.06.014. Epub 2015 Jul 2.
7
Induced Pluripotent Stem Cells for Disease Modeling and Drug Discovery in Neurodegenerative Diseases.用于神经退行性疾病建模和药物发现的诱导多能干细胞
Mol Neurobiol. 2015 Aug;52(1):244-55. doi: 10.1007/s12035-014-8867-6. Epub 2014 Aug 23.
本文引用的文献
1
Human iPSC-based modeling of late-onset disease via progerin-induced aging.基于人诱导多能干细胞的早衰症模型通过早衰素诱导衰老。
Cell Stem Cell. 2013 Dec 5;13(6):691-705. doi: 10.1016/j.stem.2013.11.006.
2
Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons.在帕金森病患者来源的神经元中鉴定和挽救α-突触核蛋白毒性。
Science. 2013 Nov 22;342(6161):983-7. doi: 10.1126/science.1245296. Epub 2013 Oct 24.
3
Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion.针对 C9ORF72 重复扩展的 ALS 患者诱导多能干细胞源性运动神经元中的 RNA 焦点。
Sci Transl Med. 2013 Oct 23;5(208):208ra149. doi: 10.1126/scitranslmed.3007529.
4
Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development.人胚胎干细胞源性前脑内神经元的功能成熟需要延长时间，并模拟人类神经发育。
Cell Stem Cell. 2013 May 2;12(5):573-86. doi: 10.1016/j.stem.2013.04.005.
5
Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness.利用 iPS 细胞建立阿尔茨海默病模型揭示了与细胞内 Aβ 相关的应激表型和药物反应的差异。
Cell Stem Cell. 2013 Apr 4;12(4):487-96. doi: 10.1016/j.stem.2013.01.009. Epub 2013 Feb 21.
6
Progressive degeneration of human neural stem cells caused by pathogenic LRRK2.致病性 LRRK2 导致人类神经干细胞进行性退化。
Nature. 2012 Nov 22;491(7425):603-7. doi: 10.1038/nature11557. Epub 2012 Oct 17.
7
Modeling human cortical development in vitro using induced pluripotent stem cells.利用诱导多能干细胞体外模拟人类皮质发育。
Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12770-5. doi: 10.1073/pnas.1202944109. Epub 2012 Jul 3.
8
Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells.利用诱导多能干细胞探究散发性和家族性阿尔茨海默病。
Nature. 2012 Jan 25;482(7384):216-20. doi: 10.1038/nature10821.
9
SNCA triplication Parkinson's patient's iPSC-derived DA neurons accumulate α-synuclein and are susceptible to oxidative stress.SNCA 三重复制帕金森病患者的 iPSC 衍生的 DA 神经元积累α-突触核蛋白，并易受氧化应激影响。
PLoS One. 2011;6(11):e26159. doi: 10.1371/journal.pone.0026159. Epub 2011 Nov 16.
10
LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress.LRRK2 突变型 iPSC 衍生的 DA 神经元对氧化应激的敏感性增加。
Cell Stem Cell. 2011 Mar 4;8(3):267-80. doi: 10.1016/j.stem.2011.01.013.
Zotero 插件