Schmidt J B, Pinzker H, Eibl M
Z Hautkr. 1986 Oct 1;61(19):1397-404.
Severe forms of acne, characterized by predominance of inflammatory reactions and persistence of the disease for years, still present therapeutic problems. The purpose of our study was to investigate the role of the immune system in severe persisting forms of acne by means of determination of cellular and humoral immunobiological parameters. The study was performed on 52 patients (47 males and 5 females) having suffered from severe acne for six years on an average, including papulopustular acne grade IV resistant to therapy, nodulocystic acne, conglobate acne, and acne tetrade. The results were compared with those of 52 healthy controls of the same age showing no inflammatory diseases, who were tested on the same day. In 56% of the acne patients, one or more parameters showed pathological values, while in nodulocystic and conglobate acne there were similar results with regard to cellular defects and acute phase reactants. The lymphocytic proliferation induced by mitogens was significantly decreased in 35% of the acne patients. We assume that the immunodeficiency observed in these patients may be mainly secondary; however, it may contribute to the perpetuance of the disease and its resistance to therapy.
重度痤疮以炎症反应为主且病程持续数年，目前仍存在治疗难题。我们研究的目的是通过测定细胞和体液免疫生物学参数，来探究免疫系统在重度持续性痤疮中的作用。该研究对52例患者（47例男性和5例女性）进行，这些患者平均患有重度痤疮6年，包括对治疗耐药的IV级丘疹脓疱型痤疮、结节囊肿型痤疮、聚合性痤疮和暴发性痤疮。研究结果与52名同龄且无炎症性疾病的健康对照者同日检测的结果进行比较。56%的痤疮患者一项或多项参数显示为病理值，而在结节囊肿型和聚合性痤疮中，细胞缺陷和急性期反应物方面有类似结果。35%的痤疮患者中，丝裂原诱导的淋巴细胞增殖显著降低。我们认为在这些患者中观察到的免疫缺陷可能主要是继发性的；然而，它可能导致疾病的持续存在及其对治疗的抵抗。
