Woscoff A, Bozzola C J, Trotta M C
Med Cutan Ibero Lat Am. 1976;4(6):449-62.
In severe forms of acne (grade IV) there is probably an inmunological alteration consisting of: 1) Alterations in the IgG. 2) They may be produced in small quantity or destroyed more rapidly. 3) Cellular immunity is normal using PHA and diminished with habitual tests. 4) It is necessary to normalize these globulin levels before or during specific medication, with antibiotics or sulfa drugs. 5) Essential aminoacids should be given so as to raise the inmunoglobulins to normal levels. The administration of commercial inmunoglobulins should be avoided, because, for genetic reason, they could produce autoimmunity or isosensibility and diminished the levels one is trying to raise.
在严重的痤疮形式（IV级）中，可能存在一种免疫改变，包括：1）IgG的改变。2）它们可能产生量少或被更快地破坏。3）使用PHA时细胞免疫正常，而常规检测时细胞免疫减弱。4）在使用抗生素或磺胺类药物进行特定药物治疗之前或期间，有必要使这些球蛋白水平正常化。5）应给予必需氨基酸，以使免疫球蛋白水平恢复正常。应避免使用商业免疫球蛋白，因为出于遗传原因，它们可能产生自身免疫或同种敏感性，并降低人们试图提高的水平。
