Wallengren J, Möller H
Acta Derm Venereol. 1986;66(5):375-80.
Topical application of capsaicin is thought to deplete substance P from local sensory nerve terminals. In experiments on human skin inflammation was induced by injection of substance P (SP) or histamine intradermally, UV irradiation, non-immunologic contact urticaria, tuberculin reaction, contact allergens and benzalkonium chloride with or without capsaicin pretreatment. The flare response to SP and histamine was suppressed by capsaicin pretreatment whereas the wheal was enlarged. Interestingly, capsaicin pretreatment enhanced the responses to all other inflammatory agents.
辣椒素的局部应用被认为可使局部感觉神经末梢中的P物质耗竭。在人体皮肤实验中，通过皮内注射P物质（SP）或组胺、紫外线照射、非免疫性接触性荨麻疹、结核菌素反应、接触性变应原以及使用或不使用辣椒素预处理的苯扎氯铵来诱发炎症。辣椒素预处理可抑制对SP和组胺的潮红反应，而风团则会增大。有趣的是，辣椒素预处理增强了对所有其他炎症介质的反应。
