Department of Internal Medicine, Bassett Medical Center and Columbia University College of Physicians and Surgeons, Cooperstown, NY.
Department of Pathology, Columbia University College of Physicians and Surgeons, New York, NY.
Am J Kidney Dis. 2014 Apr;63(4):696-9. doi: 10.1053/j.ajkd.2013.10.045. Epub 2013 Dec 4.
Granulomatous interstitial nephritis (GIN) is a rare histologic disease. Various causes have been reported in the literature, including drugs, sarcoidosis, and infections. Other incidents have no discernible cause and are identified as idiopathic. We report a 68-year-old white man who presented with acute kidney injury and was given a diagnosis of idiopathic GIN. Mycophenolate mofetil treatment was elected because of steroid toxicity. He responded well to mycophenolate mofetil and has been in remission for more than 3 years. To our knowledge, this is the first report of successful treatment with mycophenolate mofetil of an adult patient with idiopathic GIN.
肉芽肿性间质性肾炎（GIN）是一种罕见的组织学疾病。文献中报道了各种病因，包括药物、结节病和感染。其他病例则没有明显的病因，被认定为特发性。我们报告了一例 68 岁白人男性，因急性肾损伤就诊，被诊断为特发性 GIN。由于类固醇毒性，选择霉酚酸酯治疗。他对霉酚酸酯治疗反应良好，且已缓解超过 3 年。据我们所知，这是首例报道的霉酚酸酯成功治疗特发性 GIN 成年患者的病例。
