Turrentine Mark
Kelsey-Seybold Clinic, Department of Obstetrics and Gynecology, Houston, TX.
Am J Obstet Gynecol. 2014 Jul;211(1):15-7. doi: 10.1016/j.ajog.2013.12.010. Epub 2013 Dec 4.
Despite progress in preventing infant group B streptococcal disease, group B streptococcus remains the leading cause of early-onset neonatal sepsis in the United States. Fortunately, most women who are colonized with group B streptococcus receive therapy and antibiotic prophylaxis is effective. However, the only factor associated with missed chemoprophylaxis is the short duration of time between hospital admission and delivery. Although antibiotic prophylaxis given for at least 2 hours shows some pharmacological benefit, the most effective method of preventing early-onset group B streptococcus disease is 4 hours of therapy. Intrapartum management strategies might be modified to improve the efficacy of antibiotic exposure. Obstetricians should consider strengthening the beneficial effect of intrapartum antibiotic prophylaxis for infants exposed to group B streptococcus by providing at least 4 hours of treatment coverage.
尽管在预防婴儿B族链球菌病方面取得了进展，但B族链球菌仍然是美国早发性新生儿败血症的主要原因。幸运的是，大多数携带B族链球菌的女性接受了治疗，抗生素预防是有效的。然而，与错过化学预防相关的唯一因素是入院至分娩的时间间隔短。虽然至少给予2小时的抗生素预防显示出一定的药理学益处，但预防早发性B族链球菌病的最有效方法是4小时的治疗。产时管理策略可能需要调整以提高抗生素暴露的效果。产科医生应考虑通过提供至少4小时的治疗覆盖来加强对暴露于B族链球菌的婴儿的产时抗生素预防的有益效果。
