Department of Public Health, China Medical University, Taichung, Taiwan, Republic of China.
Department of Healthcare Management, Yuanpei University of Medical Technology, Hsinchu, Taiwan, Republic of China.
BMC Public Health. 2018 Apr 2;18(1):438. doi: 10.1186/s12889-018-5358-0.
We examined the risk for Group B streptococcus (GBS)-related diseases in newborns born to mothers who participated in a universal GBS screening program and to determine whether differences are observed in factors affecting the morbidity for neonatal early-onset GBS-related diseases.
This is a retrospective study and the study subjects were women who had undergone GBS screening and who gave birth naturally and their newborns between April 15, 2012 and December 31, 2013. Data from the GBS screening system database and the National Health Insurance database were collected to calculate the GBS prevalence in pregnant women and morbidity of newborns with early-onset GBS-related diseases.
The GBS prevalence in pregnant women who gave birth naturally was 19.58%. The rate of early-onset infection caused by GBS in newborns decreased from the original 0.1% to 0.02%, a decrease of as high as 80%. After the implementation of the universal GBS screening program, only three factors, including positive GBS screening result (OR = 2.84), CCI (OR = 2.45), and preterm birth (OR = 4.81) affected the morbidity for neonatal early-onset GBS-related diseases, whereas other factors had no significant impact.
The implementation of the universal GBS screening program decreased the infection rate of neonatal early-onset GBS diseases. The effects of socioeconomic factors and high-risk pregnancy on early-onset GBS infections were weakened.
我们研究了参加普遍的 B 组链球菌（GBS）筛查计划的母亲所生新生儿患 GBS 相关疾病的风险，并确定是否观察到影响新生儿早发性 GBS 相关疾病发病率的因素存在差异。
这是一项回顾性研究，研究对象为在 2012 年 4 月 15 日至 2013 年 12 月 31 日期间接受 GBS 筛查并自然分娩的妇女及其新生儿。从 GBS 筛查系统数据库和国家健康保险数据库中收集数据，以计算孕妇的 GBS 流行率和早发性 GBS 相关疾病新生儿的发病率。
自然分娩孕妇的 GBS 流行率为 19.58%。新生儿 GBS 早发性感染率从原来的 0.1%下降到 0.02%，降幅高达 80%。在实施普遍 GBS 筛查计划后，只有 GBS 筛查阳性（OR=2.84）、CCI（OR=2.45）和早产（OR=4.81）三个因素影响新生儿早发性 GBS 相关疾病的发病率，而其他因素则没有显著影响。
实施普遍的 GBS 筛查计划降低了新生儿早发性 GBS 疾病的感染率。社会经济因素和高危妊娠对早发性 GBS 感染的影响减弱。
