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迈向去势抵抗性前列腺癌的共同治疗框架:泌尿肿瘤学与医学肿瘤学相互作用的模型

Toward a common therapeutic framework in castration-resistant prostate cancer: a model for urologic oncology and medical oncology interaction.

作者信息

de Vere White Ralph, Lara Primo N

出版信息

Urol Oncol. 2014 May;32(4):380-2. doi: 10.1016/j.urolonc.2013.09.010.

DOI:10.1016/j.urolonc.2013.09.010
PMID:24316022
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4444361/
Abstract

BACKGROUND

The rapid evolution of palliative therapeutic choices in the last few years for patients with advanced castration-resistant prostate cancer (CRPC) has resulted in a dilemma currently troubling a few other epithelial malignancies: which systemic agent to choose and at what time? In addition, which specialty specifically directs the delivery of such care--Urology or Medical Oncology--has not been clearly established.

APPROACH

Recognizing the lack of consensus, we propose a framework for Urology and Medical Oncology interactions that is founded on models that have succeeded in the past.

CONCLUSION

This approach aims to focus the care on the patient with CRPC rather than on his physicians and promises to improve patient outcomes in this disease state.

摘要

背景

在过去几年中,晚期去势抵抗性前列腺癌(CRPC)患者姑息治疗选择的迅速演变,导致了目前困扰其他一些上皮性恶性肿瘤的困境:选择哪种全身治疗药物以及何时选择?此外,尚未明确确定具体由哪个专科——泌尿外科还是医学肿瘤学——来指导此类治疗的实施。

方法

认识到缺乏共识,我们提出了一个泌尿外科与医学肿瘤学相互作用的框架,该框架基于过去成功的模式。

结论

这种方法旨在将治疗重点放在CRPC患者身上,而不是其医生身上,并有望改善这种疾病状态下的患者预后。

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本文引用的文献

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Alpha emitter radium-223 and survival in metastatic prostate cancer.α 粒子发射体镭-223 与转移性前列腺癌的生存。
N Engl J Med. 2013 Jul 18;369(3):213-23. doi: 10.1056/NEJMoa1213755.
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Multidisciplinary care and management selection in prostate cancer.前列腺癌的多学科治疗和管理选择。
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Role of targeted agents in metastatic colorectal cancer.靶向药物在转移性结直肠癌中的作用。
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Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.多西他赛治疗后进展的转移性去势抵抗性前列腺癌患者中,泼尼松联合卡巴他赛或米托蒽醌治疗的随机开放标签试验。
Lancet. 2010 Oct 2;376(9747):1147-54. doi: 10.1016/S0140-6736(10)61389-X.
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Sipuleucel-T immunotherapy for castration-resistant prostate cancer.西普利单抗免疫治疗去势抵抗性前列腺癌。
N Engl J Med. 2010 Jul 29;363(5):411-22. doi: 10.1056/NEJMoa1001294.
10
Treatment options in metastatic renal carcinoma: an embarrassment of riches.转移性肾癌的治疗选择:选择过多令人为难。
J Clin Oncol. 2006 Jan 1;24(1):1-3. doi: 10.1200/JCO.2005.03.7234. Epub 2005 Dec 5.