Nagai Clinic, 607-1 Kamihikona, Misato, Saitama 341-0004, Japan.
Nagai Clinic, 607-1 Kamihikona, Misato, Saitama 341-0004, Japan.
Reprod Biomed Online. 2014 Mar;28(3):401-4. doi: 10.1016/j.rbmo.2013.10.024. Epub 2013 Nov 15.
Germinal-vesicle (GV) transfer, spindle-chromosome complex transfer in metaphase-II oocytes and two pronuclei transfer have been evaluated as possible treatments for patients who have mitochondrial diseases. However, GV transfers often lead to heteroplasmy while the other two methods are frequently associated with aneuploidy. The present study used a new method based on the transfer of aggregated chromosomes, which occurs in human oocytes, before the metaphase spindle is established.
生殖泡（GV）转移、中期 II 期卵母细胞中的纺锤体-染色体复合物转移和两个原核转移已被评估为线粒体疾病患者的可能治疗方法。然而，GV 转移通常会导致异质体，而其他两种方法则经常与非整倍体有关。本研究使用了一种新方法，该方法基于在中期纺锤体形成之前聚集染色体的转移，这种转移发生在人类卵母细胞中。
