Medical Intensive Care Unit, Hospital Mohammed V, El Jadida, Morocco; Laboratory of Biochemistry and Neuroscience, Faculty of Science and Technology, University Hassan 1, 26000 Settat, Morocco.
Medical Intensive Care Unit, Hospital Mohammed V, El Jadida, Morocco.
Toxicon. 2014 Feb;78:78-82. doi: 10.1016/j.toxicon.2013.11.016. Epub 2013 Dec 4.
For several decades, Morocco is confronted to medico-social problem of scorpion stings and envenomations. In 2009, epidemiological data established by the Poison Control Center recorded 29,816 stung patients, with an incidence of 1.1‰ and a fatality rate of 0.18%. The neurotoxins from scorpion venom are potent activators of the autonomic nervous system resulting a physiopathological disorder of vital systems. The most serious clinical manifestations are neurotoxic effects, pulmonary edema and cardiovascular distress. This present work reports the cases of three children (4 years and 6 months, 8 months and 15 days, 4 years), hospitalized in intensive care for an envenomation by Androctonus mauritanicus (the most fatal scorpion specie). The children presented cardiac dysfunction where pulmonary edema and state of shock were complications resultants. Two cases survived after supportive and symptomatic treatment based on dobutamine as primordial treatment in cardiovascular and pulmonary correction and other drugs. The third case died. The objective of this work was to detect the limit of the effectiveness of symptomatic treatment during a severe scorpion envenomation.
几十年来,摩洛哥一直面临着蝎子蜇伤和中毒的医学社会问题。2009 年,中毒控制中心建立的流行病学数据记录了 29816 名被蜇伤的患者,发病率为 1.1‰,死亡率为 0.18%。蝎子毒液中的神经毒素是自主神经系统的有效激活剂,导致生命系统的病理生理紊乱。最严重的临床表现是神经毒性作用、肺水肿和心血管窘迫。本研究报告了三例儿童(4 岁零 6 个月、8 个月零 15 天、4 岁)因被北非黑肥尾蝎(最致命的蝎子物种)蜇伤而住院接受重症监护的病例。儿童表现出心脏功能障碍,肺水肿和休克是由此产生的并发症。两例在基于多巴酚丁胺的支持和对症治疗后存活,多巴酚丁胺是心血管和肺纠正以及其他药物的基本治疗方法。第三例死亡。本研究的目的是检测在严重蝎子蜇伤期间对症治疗的效果极限。