胱硫醚β合酶 844ins68 多态性与神经管缺陷易感性无关。
Cystathionine beta-synthase 844ins68 polymorphism is unrelated to susceptibility to neural tube defects.
机构信息
Dept. of Biochemistry, Capital Institute of Pediatrics, Beijing 100020, China.
Dept. of Biochemistry, Capital Institute of Pediatrics, Beijing 100020, China.
出版信息
Gene. 2014 Feb 10;535(2):119-23. doi: 10.1016/j.gene.2013.11.052. Epub 2013 Dec 4.
OBJECTIVE
Cystathionine beta-synthase (CBS) 844ins68 polymorphism has been implicated in the development of neural tube defects (NTDs). However, the results of different studies are inconsistent. Thus, we conducted a meta-analysis to further investigate this association.
METHODS
Published studies were retrieved from PubMed, Embase, China National Knowledge Infrastructure, and Wanfang Data. Studies that evaluated the association between CBS 844ins68 polymorphism and NTD risk among mothers, children, or fathers were included. The pooled odds ratios with 95% confidence interval were calculated using a fixed effects model or a random effects model.
RESULTS
A total of eight studies on mothers (641 cases and 1145 controls), eight studies on children (852 cases and 1912 controls), and five studies (263 cases and 1562 controls) on fathers were included. The meta-analysis revealed no significant association between CBS 844ins68 polymorphism and NTD risk among mothers, children, and fathers under either genetic model.
CONCLUSION
The present meta-analysis indicates that CBS 844ins68 polymorphism is not a good predictor of risk for NTDs.
目的
胱硫醚β-合酶（CBS）844ins68 多态性与神经管缺陷（NTD）的发生有关。然而，不同研究的结果并不一致。因此，我们进行了荟萃分析以进一步研究这种关联。
方法
从 PubMed、Embase、中国知网和万方数据中检索已发表的研究。纳入评估 CBS 844ins68 多态性与母亲、儿童或父亲 NTD 风险之间关联的研究。使用固定效应模型或随机效应模型计算合并的优势比及其 95%置信区间。
结果
共纳入 8 项关于母亲（641 例病例和 1145 例对照）、8 项关于儿童（852 例病例和 1912 例对照）和 5 项关于父亲（263 例病例和 1562 例对照）的研究。荟萃分析显示，CBS 844ins68 多态性与母亲、儿童和父亲的 NTD 风险之间无显著关联，无论采用何种遗传模型。
结论
本荟萃分析表明 CBS 844ins68 多态性不是 NTD 风险的良好预测因子。
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