Imani Mohammad Moslem, Safaei Mohsen, Sadeghi Masoud
Department of Orthodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Advanced Dental Sciences Research Laboratory, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Int Orthod. 2019 Dec;17(4):652-659. doi: 10.1016/j.ortho.2019.08.018. Epub 2019 Sep 5.
Both genetics and environmental factors play a role in the occurrence of non-syndromic cleft lip/palate (NSCL/P). This meta-analysis evaluated the association between cystathionine beta-synthase (CBS) c.844ins68 polymorphism and risk of NSCL/P in family-based and case-control studies.
The PubMed, Web of Science, Scopus, and Cochrane Library databases were searched for articles published until September 2018. RevMan 5.3 software was used to calculate the odds ratio (OR) for the association between CBS c.844ins68 polymorphism and risk of NSCL/P by using five genetic models in the studies. The transmission disequilibrium test (TDT) was conducted for family-based studies.
Three case-control and three family-based studies were evaluated. Based on the analysis of five genetic models, risk of NSCL/P was not related to CBS c.844ins68 polymorphism in case-control studies. The results of family-based studies did not show any association between the CBS c.844ins68 allele and NSCL/P either.
The results of this meta-analysis showed that there was no association between CBS c.844ins68 polymorphism and risk of NSCL/P; therefore, this polymorphism does not play a role in susceptibility to NSCL/P.
遗传因素和环境因素均在非综合征性唇腭裂（NSCL/P）的发生中起作用。本荟萃分析在基于家系和病例对照的研究中评估了胱硫醚β合酶（CBS）基因c.844ins68多态性与NSCL/P风险之间的关联。
检索PubMed、Web of Science、Scopus和Cochrane图书馆数据库，查找截至2018年9月发表的文章。使用RevMan 5.3软件，通过研究中的五种遗传模型计算CBS基因c.844ins68多态性与NSCL/P风险关联的比值比（OR）。对基于家系的研究进行传递不平衡检验（TDT）。
评估了三项病例对照研究和三项基于家系的研究。基于五种遗传模型的分析，病例对照研究中NSCL/P的风险与CBS基因c.844ins68多态性无关。基于家系的研究结果也未显示CBS基因c.844ins68等位基因与NSCL/P之间存在任何关联。
本荟萃分析结果表明，CBS基因c.844ins68多态性与NSCL/P风险之间无关联；因此，这种多态性在NSCL/P易感性中不起作用。
