Department of Polymer Science & Engineering and Key Laboratory of Mesoscopic Chemistry of MOE, School of Chemistry & Chemical Engineering, Nanjing University, Nanjing, 210093, China.
Nanoscale. 2014;6(3):1480-9. doi: 10.1039/c3nr04430k.
The present study describes a flexible nanoplatform based on electrostatic assembly of conjugated polyelectrolytes (CPEs) and carboxylated multi-walled carbon nanotubes (cMWNTs). It is demonstrated that the obtained nanocomposites inherit intrinsic optical properties of CPEs and characteristic Raman vibration modes of MWNTs, providing a fluorescence-Raman dual-imaging method for intracellular tracking and locating of MWNTs. We suggest that the cellular internalization of the CPE-cMWNT nanocomposites is a surface charge-dependent process. The strengths of this nanoplatform include satisfying biocompatibility, enhanced protein-repellent property, and ease of implementation, making it available for both in vitro and in vivo applications.
本研究描述了一种基于静电组装的共轭聚合物电解质 (CPEs) 和羧基化多壁碳纳米管 (cMWNTs) 的柔性纳米平台。研究表明，所得到的纳米复合材料继承了 CPEs 的固有光学性质和 MWNTs 的特征拉曼振动模式，为 MWNTs 的细胞内跟踪和定位提供了荧光-拉曼双成像方法。我们认为，CPE-cMWNT 纳米复合材料的细胞内化是一个依赖于表面电荷的过程。该纳米平台的优点包括良好的生物相容性、增强的抗蛋白性质以及易于实施，使其可用于体外和体内应用。
