Qian Cheng-Gen, Chen Yu-Lei, Feng Pei-Jian, Xiao Xuan-Zhong, Dong Mei, Yu Ji-Cheng, Hu Quan-Yin, Shen Qun-Dong, Gu Zhen
Department of Polymer Science and Engineering and Key Laboratory of High Performance Polymer Materials and Technology of MOE, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA.
Acta Pharmacol Sin. 2017 Jun;38(6):764-781. doi: 10.1038/aps.2017.42. Epub 2017 May 29.
Conjugated polymer nanomaterials (CPNs), as optically and electronically active materials, hold promise for biomedical imaging and drug delivery applications. This review highlights the recent advances in the utilization of CPNs in theranostics. Specifically, CPN-based in vivo imaging techniques, including near-infrared (NIR) imaging, two-photon (TP) imaging, photoacoustic (PA) imaging, and multimodal (MM) imaging, are introduced. Then, CPN-based photodynamic therapy (PDT) and photothermal therapy (PTT) are surveyed. A variety of stimuli-responsive CPN systems for drug delivery are also summarized, and the promising trends and translational challenges are discussed.
共轭聚合物纳米材料（CPNs）作为光学和电子活性材料，在生物医学成像和药物递送应用方面具有潜力。本综述重点介绍了CPNs在治疗诊断学中的最新进展。具体而言，介绍了基于CPNs的体内成像技术，包括近红外（NIR）成像、双光子（TP）成像、光声（PA）成像和多模态（MM）成像。然后，对基于CPNs的光动力疗法（PDT）和光热疗法（PTT）进行了综述。还总结了用于药物递送的各种刺激响应性CPN系统，并讨论了其前景趋势和转化挑战。
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