移植中的固有免疫细胞。
Innate immune cells in transplantation.
机构信息
aDepartment of Surgery bDepartment of Pathology & Immunology, Washington University in St. Louis, St. Louis, Missouri, USA.
出版信息
Curr Opin Organ Transplant. 2014 Feb;19(1):14-9. doi: 10.1097/MOT.0000000000000041.
Abstract
PURPOSE OF REVIEW
To examine the recent literature on the role of innate cells in immunity to transplanted tissue. It specifically addresses the impact of monocytes/macrophages, neutrophils, natural killer cells, and platelets.
RECENT FINDINGS
Current research indicates that innate immunity plays a dual role in response to transplanted tissue with the ability to either facilitate rejection or promote tolerance. Intriguingly, some of these cells are even capable of reacting to allogeneic cells, a feature usually only attributed to cells of the adaptive immune system.
SUMMARY
This review highlights the new therapeutic targets in the innate immune system that may be useful in the treatment of transplant recipients. It also emphasizes the need to use caution in exploring these new therapeutics.
摘要
目的综述
探讨固有细胞在移植组织免疫中的作用的最新文献。它特别涉及单核细胞/巨噬细胞、中性粒细胞、自然杀伤细胞和血小板的作用。
最近的发现
目前的研究表明，固有免疫在对移植组织的反应中起双重作用，既能促进排斥反应，也能促进耐受。有趣的是，其中一些细胞甚至能够对同种异体细胞产生反应，而这种特性通常只归因于适应性免疫系统的细胞。
总结
本综述强调了固有免疫系统中的新治疗靶点，这可能对移植受者的治疗有用。它还强调了在探索这些新疗法时需要谨慎。
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Innate immune cells in transplantation.移植中的固有免疫细胞。
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2
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本文引用的文献
1
Macrophage MHC and T-cell receptors essential for rejection of allografted skin and lymphoma.巨噬细胞 MHC 和 T 细胞受体对于排斥同种异体皮肤移植物和淋巴瘤是必需的。
Transplantation. 2013 Aug 15;96(3):251-7. doi: 10.1097/TP.0b013e3182985527.
2
HLA class I antibodies trigger increased adherence of monocytes to endothelial cells by eliciting an increase in endothelial P-selectin and, depending on subclass, by engaging FcγRs.HLA Ⅰ类抗体通过诱导内皮细胞 P 选择素增加，并根据亚类通过结合 FcγR，触发单核细胞与内皮细胞的黏附增加。
J Immunol. 2013 Jun 15;190(12):6635-50. doi: 10.4049/jimmunol.1201434. Epub 2013 May 20.
3
Hmgb1-TLR4-IL-23-IL-17A axis promote ischemia-reperfusion injury in a cardiac transplantation model.Hmgb1-TLR4-IL-23-IL-17A 轴促进心脏移植模型中的缺血再灌注损伤。
Transplantation. 2013 Jun 27;95(12):1448-54. doi: 10.1097/TP.0b013e318293b7e1.
4
Macrophage depletion impairs corneal wound healing after autologous transplantation in mice.巨噬细胞耗竭可损害小鼠自体移植后角膜的愈合。
PLoS One. 2013 Apr 16;8(4):e61799. doi: 10.1371/journal.pone.0061799. Print 2013.
5
Cytokine complex-expanded natural killer cells improve allogeneic lung transplant function via depletion of donor dendritic cells.细胞因子复合物扩增的自然杀伤细胞通过耗竭供体树突状细胞改善同种异体肺移植功能。
Am J Respir Crit Care Med. 2013 Jun 15;187(12):1349-59. doi: 10.1164/rccm.201209-1749OC.
6
Mononuclear inflammatory infiltrate and microcirculation injury in acute rejection: role in renal allograft survival.单核炎性浸润和微循环损伤在急性排斥反应中的作用：对肾移植存活的影响。
Ren Fail. 2013;35(5):601-6. doi: 10.3109/0886022X.2013.780150. Epub 2013 Apr 8.
7
Intravascular macrophages in cardiac allograft biopsies for diagnosis of early and late antibody-mediated rejection.心脏移植活检中的血管内巨噬细胞在早期和晚期抗体介导排斥反应诊断中的应用。
J Heart Lung Transplant. 2013 Apr;32(4):404-9. doi: 10.1016/j.healun.2012.12.017.
8
TNFα from classically activated macrophages accentuates epithelial to mesenchymal transition in obliterative bronchiolitis.经典激活的巨噬细胞产生的 TNFα 加重闭塞性细支气管炎中的上皮间质转化。
Am J Transplant. 2013 Mar;13(3):621-33. doi: 10.1111/ajt.12065. Epub 2013 Jan 17.
9
Pathologic findings in lung allografts with anti-HLA antibodies.抗 HLA 抗体肺移植的病理解剖发现。
J Heart Lung Transplant. 2013 Mar;32(3):326-32. doi: 10.1016/j.healun.2012.11.018. Epub 2013 Jan 10.
10
Blockade of p-selectin is sufficient to reduce MHC I antibody-elicited monocyte recruitment in vitro and in vivo.阻断 P-选择素足以减少 MHC I 抗体引发的体外和体内单核细胞募集。
Am J Transplant. 2013 Feb;13(2):299-311. doi: 10.1111/ajt.12016. Epub 2012 Dec 27.
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