移植中的天然同种异体识别。
Innate allorecognition in transplantation.
机构信息
Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania.
Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania.
出版信息
J Heart Lung Transplant. 2021 Jul;40(7):557-561. doi: 10.1016/j.healun.2021.03.018. Epub 2021 Mar 29.
Successful allogeneic transplantation has been made possible by suppressing activation of the adaptive immune system. Current immunosuppressive therapy prevents rejection by targeting T and B cells. Despite this effective treatment, it is the innate immune system, which includes dendritic cells, monocytes, natural killer cells, that is responsible for the initiation of the adaptive immune response. Recent work has described that the innate immune system is capable of recognizing allogeneic nonself and some of the mechanisms of innate allorecognition have been uncovered. Better understanding of the role of the innate immune system in initiation and maintenance of the allo-immune response has potential to lead to better treatment strategies for transplant patients, prolonging allograft survival. Here, we review advances in our understanding of innate allorecognition in transplantation.
成功的同种异体移植已经成为可能，这要归功于对适应性免疫系统的抑制。目前的免疫抑制疗法通过靶向 T 和 B 细胞来预防排斥反应。尽管这种治疗方法很有效，但正是包括树突状细胞、单核细胞、自然杀伤细胞在内的固有免疫系统负责启动适应性免疫反应。最近的研究工作描述了固有免疫系统能够识别同种异体非自身，并且已经揭示了一些固有免疫识别的机制。更好地理解固有免疫系统在启动和维持同种免疫反应中的作用，有可能为移植患者带来更好的治疗策略，延长移植物的存活时间。在这里，我们回顾了在移植中对固有免疫识别的理解的进展。
Zotero 插件