基因检测在预测和治疗肥胖症方面有价值吗？
Is genetic testing of value in predicting and treating obesity?
作者信息
Ng Maggie C Y, Bowden Donald W
机构信息
Center for Genomics and Personalized Medicine Research and Center for Diabetes Research, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA.
出版信息
N C Med J. 2013 Nov-Dec;74(6):530-3.
Abstract
Obesity is a multifactorial disease resulting from the interaction between genetic factors and lifestyle. Identification of rare genetic variations with strong effects on obesity has been useful in diagnosing and designing personalized therapy for early-onset or syndromic obesity. However, common variants identified in recent genome-wide association studies have limited clinical value.
摘要
肥胖是一种由遗传因素和生活方式相互作用导致的多因素疾病。识别对肥胖有强烈影响的罕见基因变异，对于诊断和设计早发性或综合征性肥胖的个性化治疗很有用。然而，最近全基因组关联研究中发现的常见变异临床价值有限。
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2
Obesity genomics: assessing the transferability of susceptibility loci across diverse populations.肥胖基因组学：评估易感性位点在不同人群中的可转移性。
Genome Med. 2013 Jun 28;5(6):55. doi: 10.1186/gm459. eCollection 2013.
3
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Biodemography Soc Biol. 2013;59(1):85-100. doi: 10.1080/19485565.2013.774628.
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5
The genetics of human obesity.人类肥胖的遗传学
Ann N Y Acad Sci. 2013 Apr;1281(1):178-90. doi: 10.1111/nyas.12020. Epub 2013 Jan 29.
6
Adult onset global loss of the fto gene alters body composition and metabolism in the mouse.成年期全脑缺失 fto 基因改变小鼠的体成分和代谢。
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7
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8
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