Ng Maggie C Y, Bowden Donald W
Center for Genomics and Personalized Medicine Research and Center for Diabetes Research, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA.
N C Med J. 2013 Nov-Dec;74(6):530-3.
Obesity is a multifactorial disease resulting from the interaction between genetic factors and lifestyle. Identification of rare genetic variations with strong effects on obesity has been useful in diagnosing and designing personalized therapy for early-onset or syndromic obesity. However, common variants identified in recent genome-wide association studies have limited clinical value.
肥胖是一种由遗传因素和生活方式相互作用导致的多因素疾病。识别对肥胖有强烈影响的罕见基因变异，对于诊断和设计早发性或综合征性肥胖的个性化治疗很有用。然而，最近全基因组关联研究中发现的常见变异临床价值有限。
