Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA, UK.
Chem Commun (Camb). 2014 Feb 7;50(10):1175-7. doi: 10.1039/c3cc47581f.
A convenient method for the synthesis of fluoromethylated carnitine biosynthesis intermediates, i.e. fluorinated derivatives of γ-butyrobetaine and trimethyllysine, is described. The fluoromethylated probes were useful in both in vitro and cell based assays employing (19)F NMR and LC-MS analyses.
描述了一种方便的合成氟甲基肉碱生物合成中间体的方法，即γ-丁氧基甜菜碱和三甲赖氨酸的氟化衍生物。氟甲基探针可用于（19）F NMR 和 LC-MS 分析的体外和基于细胞的测定。
