Rydzik Anna M, Leung Ivanhoe K H, Kochan Grazyna T, McDonough Michael A, Claridge Timothy D W, Schofield Christopher J
Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA (UK).
Angew Chem Int Ed Engl. 2014 Oct 6;53(41):10925-7. doi: 10.1002/anie.201406125. Epub 2014 Aug 27.
γ-Butyrobetaine hydroxylase (BBOX) is a 2-oxoglutarate dependent oxygenase that catalyzes the final hydroxylation step in the biosynthesis of carnitine. BBOX was shown to catalyze the oxidative desymmetrization of achiral N,N-dialkyl piperidine-4-carboxylates to give products with two or three stereogenic centers.
γ-丁酰甜菜碱羟化酶（BBOX）是一种依赖2-氧代戊二酸的加氧酶，催化肉碱生物合成中的最后一步羟基化反应。已证明BBOX可催化非手性N，N-二烷基哌啶-4-羧酸酯的氧化去对称化反应，生成具有两个或三个手性中心的产物。
