1] Unit for Lymphopoiesis, Immunology Department, INSERM U668 Paris, France. [2] Université Pierre et Marie Curie, Paris, France. [3].
1] Unit for Lymphopoiesis, Immunology Department, INSERM U668 Paris, France. [2] Université Paris Diderot, Sorbonne Paris Cité, Cellule Pasteur, Paris, France. [3].
Nat Immunol. 2014 Jan;15(1):27-35. doi: 10.1038/ni.2782. Epub 2013 Dec 8.
The generation of T cells depends on the migration of hematopoietic progenitor cells to the thymus throughout life. The identity of the thymus-settling progenitor cells has been a matter of considerable debate. Here we found that thymopoiesis was initiated by a first wave of T cell lineage-restricted progenitor cells with limited capacity for population expansion but accelerated differentiation into mature T cells. They gave rise to αβ and γδ T cells that constituted Vγ3(+) dendritic epithelial T cells. Thymopoiesis was subsequently maintained by less-differentiated progenitor cells that retained the potential to develop into B cells and myeloid cells. In that second wave, which started before birth, progenitor cells had high proliferative capacity but delayed differentiation capacity and no longer gave rise to embryonic γδ T cells. Our work reconciles conflicting hypotheses on the nature of thymus-settling progenitor cells.
T 细胞的生成依赖于造血祖细胞向胸腺的终生迁移。胸腺定居祖细胞的身份一直是一个备受争议的问题。在这里，我们发现胸腺发生是由第一波具有有限增殖能力但加速分化为成熟 T 细胞的 T 细胞谱系限制祖细胞启动的。它们产生了构成 Vγ3(+)树突状上皮 T 细胞的 αβ 和 γδ T 细胞。随后，由保留发育为 B 细胞和髓样细胞潜能的分化程度较低的祖细胞维持了胸腺发生。在第二波祖细胞中，这一波祖细胞发生于出生前，具有高增殖能力，但分化能力延迟，不再产生胚胎 γδ T 细胞。我们的工作调和了关于胸腺定居祖细胞性质的相互矛盾的假说。
