Institut Pasteur, Unité de Lymphopoièse, Paris, France.
Nat Immunol. 2011 Sep 11;12(10):949-58. doi: 10.1038/ni.2105.
The transcription factor RORγt is required for the development of several innate lymphoid populations, such as lymphoid tissue-inducer cells (LTi cells) and cells that secrete interleukin 17 (IL-17) or IL-22. The progenitor cells as well as the developmental stages that lead to the emergence of RORγt(+) innate lymphoid cells (ILCs) remain undefined. Here we identify the chemokine receptor CXCR6 as an additional marker of the development of ILCs and show that common lymphoid progenitors lost B cell and T cell potential as they successively acquired expression of the integrin α(4)β(7) and CXCR6. Whereas fetal RORγt(+) cells matured in the fetal liver environment, adult bone marrow-derived RORγt(+) ILCs matured outside the bone marrow, in a Notch2-dependent manner. Therefore, fetal and adult environments influence the differentiation of RORγt(+) cells differently.
转录因子 RORγt 对于几种先天淋巴细胞群体的发育是必需的，例如淋巴组织诱导细胞（LTi 细胞）和分泌白细胞介素 17（IL-17）或白细胞介素 22 的细胞。祖细胞以及导致 RORγt(+)先天淋巴细胞（ILCs）出现的发育阶段仍未确定。在这里，我们确定趋化因子受体 CXCR6 是 ILCs 发育的另一个标志物，并表明共同淋巴祖细胞在相继获得整合素 α(4)β(7)和 CXCR6 的表达时，失去了 B 细胞和 T 细胞的潜能。而胎儿 RORγt(+)细胞在胎肝环境中成熟，成年骨髓来源的 RORγt(+)ILC 则在骨髓外以 Notch2 依赖性方式成熟。因此，胎儿和成年环境以不同的方式影响 RORγt(+)细胞的分化。
