越南苏木中新酚类化合物的细胞毒性活性
Cytotoxic activity of new phenolic compounds from Vietnamese Caesalpinia sappan.
作者信息
Hung Tran Manh, Hai Nguyen Xuan, Nhan Nguyen Trung, Quang Ton That, Quan Tran Le, Cuong To Dao, Dang Nguyen Hai, Dat Nguyen Tien
机构信息
Faculty of Chemistry, University of Science, Vietnam National University.
出版信息
Biosci Biotechnol Biochem. 2013;77(12):2378-82. doi: 10.1271/bbb.130493. Epub 2013 Dec 7.
Two new phenolic compounds, caesalpiniaphenols G-H (1 and 2), were isolated from Vietnamese Caesalpinia sappan heartwood. The chemical structures were established mainly by extensive spectroscopic studies and chemical evidence. Compounds 1 and 2 showed potent inhibitory activity against HL-60 cancer cell lines with respective IC50 values of 16.7 and 22.5 µg/mL. Treating HL-60 cells with various concentrations of 1 resulted in growth inhibition and the induction of apoptosis.
从越南苏木的心材中分离出两种新的酚类化合物，苏木酚G - H（1和2）。其化学结构主要通过广泛的光谱研究和化学证据确定。化合物1和2对HL - 60癌细胞系显示出强效抑制活性，IC50值分别为16.7和22.5 µg/mL。用不同浓度的1处理HL - 60细胞会导致生长抑制并诱导细胞凋亡。
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