Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China; Department of Pharmaceutical Engineering, Hunan University of Science and Engineering, Yongzhou 425199, China.
Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Fitoterapia. 2014 Jan;92:280-4. doi: 10.1016/j.fitote.2013.12.004. Epub 2013 Dec 12.
Two novel protosappanins, named Caesappin A (1) and B (2), along with three known protosappanins were isolated from Caesalpinia sappan L. Caesappin A is a new type protosappanin with a seven-membered ring fusing an acetal-type section. Compound 4 was isolated from the genus Caesalpinia for the first time. The structures were elucidated on the basis of spectral analysis and the absolute configuration was determined by the ECD experiment coupled with calculated ECD spectra. Their cytotoxic activities were evaluated using MTT assay.
从苏木属植物巴西苏木中分离得到了两种新的原巴西苏木素，分别命名为 Caesappin A（1）和 B（2），以及三种已知的原巴西苏木素。Caesappin A 是一种具有缩醛型部分的七元环融合的新型原巴西苏木素。化合物 4 是首次从苏木属植物中分离得到的。结构是基于光谱分析确定的，绝对构型是通过 ECD 实验结合计算 ECD 光谱确定的。采用 MTT 法评价了它们的细胞毒性活性。
