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Cell adhesion molecules: druggable targets for modulating the connectome and brain disorders?

作者信息

Uhl George R, Drgonova Jana

机构信息

Molecular Neurobiology Branch, NIH-IRP, NIDA, Baltimore, Maryland, USA.

出版信息

Neuropsychopharmacology. 2014 Jan;39(1):235. doi: 10.1038/npp.2013.240.

DOI:10.1038/npp.2013.240
PMID:24317312
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3857667/
Abstract
摘要

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本文引用的文献

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T-cadherin structures reveal a novel adhesive binding mechanism.T 钙黏蛋白结构揭示了一种新颖的黏附结合机制。
Nat Struct Mol Biol. 2010 Mar;17(3):339-47. doi: 10.1038/nsmb.1781. Epub 2010 Feb 28.
2
Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.成瘾及相关可遗传表型的分子遗传学:全基因组关联研究方法确定了具有多效性的“连接星座”和药物靶基因。
Ann N Y Acad Sci. 2008 Oct;1141:318-81. doi: 10.1196/annals.1441.018.
3
OKCAM: an ontology-based, human-centered knowledgebase for cell adhesion molecules.OKCAM:一个基于本体的、以人类为中心的细胞粘附分子知识库。
Nucleic Acids Res. 2009 Jan;37(Database issue):D251-60. doi: 10.1093/nar/gkn568. Epub 2008 Sep 12.
4
PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome.PTPRD(蛋白酪氨酸磷酸酶受体δ型)与不宁腿综合征有关。
Nat Genet. 2008 Aug;40(8):946-8. doi: 10.1038/ng.190. Epub 2008 Jul 27.
5
Mammalian motoneuron axon targeting requires receptor protein tyrosine phosphatases sigma and delta.哺乳动物运动神经元轴突靶向需要受体蛋白酪氨酸磷酸酶σ和δ。
J Neurosci. 2006 May 31;26(22):5872-80. doi: 10.1523/JNEUROSCI.0386-06.2006.
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NrCAM in addiction vulnerability: positional cloning, drug-regulation, haplotype-specific expression, and altered drug reward in knockout mice.NrCAM在成瘾易感性中的作用:定位克隆、药物调节、单倍型特异性表达以及基因敲除小鼠的药物奖赏改变
Neuropsychopharmacology. 2006 Mar;31(3):572-84. doi: 10.1038/sj.npp.1300855.