Department of Nuclear Medicine, Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London, SE1 9RT, UK.
Eur J Nucl Med Mol Imaging. 2014 May;41 Suppl 1:S26-35. doi: 10.1007/s00259-013-2643-0. Epub 2013 Dec 7.
The development of hybrid single photon emission computed tomography/computed tomography (SPECT/CT) cameras has increased the diagnostic value of many existing single photon radiopharmaceuticals. Precise anatomical localization of lesions greatly increases diagnostic confidence in bone imaging of the extremities, infection imaging, sentinel lymph node localization, and imaging in other areas. Accurate anatomical localization is particularly important prior to surgery, especially involving the parathyroid glands and sentinel lymph node procedures. SPECT/CT plays a role in characterization of lesions, particularly in bone scintigraphy and radioiodine imaging of metastatic thyroid cancer. In the development of novel tracers, SPECT/CT is particularly important in monitoring response to therapies that do not result in an early change in lesion size. Preclinical SPECT/CT devices, which actually have spatial resolution superior to PET/CT devices, have become essential in characterization of the biodistribution and tissue kinetics of novel tracers, allowing coregistration of serial studies within the same animals, which serves both to reduce biological variability and reduce the number of animals required. In conclusion, SPECT/CT increases the utility of existing radiopharmaceuticals and plays a pivotal role in the evaluation of novel tracers.
混合单光子发射计算机断层扫描/计算机断层扫描（SPECT/CT）相机的发展提高了许多现有单光子放射性药物的诊断价值。病变的精确解剖定位大大提高了四肢骨成像、感染成像、前哨淋巴结定位和其他领域成像的诊断信心。在手术前，特别是涉及甲状旁腺和前哨淋巴结手术时，准确的解剖定位尤为重要。SPECT/CT 在病变的特征描述中发挥作用，特别是在骨闪烁扫描和转移性甲状腺癌的放射性碘成像中。在新型示踪剂的开发中，SPECT/CT 在监测对治疗反应的作用非常重要，这些治疗不会导致病变大小的早期变化。具有优于 PET/CT 设备的实际空间分辨率的临床前 SPECT/CT 设备已成为新型示踪剂的生物分布和组织动力学特征描述的重要工具，允许在同一动物中对系列研究进行配准，这既可以减少生物学变异性，又可以减少所需动物的数量。总之，SPECT/CT 提高了现有放射性药物的效用，并在评估新型示踪剂方面发挥了关键作用。
