Eisemann Nora, Waldmann Annika, Rohde Volker, Katalinic Alexander
Institute of Cancer Epidemiology, University of Luebeck, Ratzeburger Allee 160, 23562, Luebeck, Germany,
Qual Life Res. 2014 Jun;23(5):1557-68. doi: 10.1007/s11136-013-0588-1. Epub 2013 Dec 8.
The diagnosis of prostate cancer and the following treatment does not only affect the patient, but also his partner. Partners often suffer even more severely from psychological distress than the patients themselves. This analysis aims to describe the quality of life (QoL) after the cancer diagnosis over time and to identify the effects of possible predictors of partners' quality of life in a German study population.
Patients with localised prostate cancer and their partners were recruited from a prospective multicenter study in Germany, the Prostate Cancer, Sexuality, and Partnership (ProCaSP) Study. At five observation times during the follow-up period of 2 years after diagnosis, QoL (EORTC QLQ-C30) and personal, social, and cancer-related health factors as well as adaptation and coping factors of 293 couples were observed and analysed with mixed effects analysis.
The men's prostate cancer diagnosis had a small, but significant impact on their partner's QoL. However, QoL of partners was most affected by the partners' own physical health and psychological condition, time, and their relationship quality.
The finding that average QoL increased again 3 months after diagnosis and later should give partners faith and hope for the future. The identified most important predictors of partners' QoL are potentially susceptible to intervention, and further research on target groups in special need of support and on adequate interventions is needed.
前列腺癌的诊断及后续治疗不仅会影响患者本人，还会对其伴侣产生影响。伴侣往往比患者本人遭受更严重的心理困扰。本分析旨在描述德国研究人群中癌症诊断后随时间变化的生活质量（QoL），并确定伴侣生活质量可能的预测因素的影响。
从德国一项前瞻性多中心研究“前列腺癌、性与伴侣关系（ProCaSP）研究”中招募患有局限性前列腺癌的患者及其伴侣。在诊断后的2年随访期内的5个观察时间点，观察并分析了293对夫妇的生活质量（EORTC QLQ-C30）以及个人、社会和癌症相关的健康因素，以及适应和应对因素，并采用混合效应分析。
男性前列腺癌诊断对其伴侣的生活质量有微小但显著的影响。然而，伴侣的生活质量受伴侣自身身体健康、心理状况、时间以及他们的关系质量影响最大。
诊断后3个月及之后平均生活质量再次提高这一发现应能给伴侣们对未来的信心和希望。已确定的伴侣生活质量最重要的预测因素可能易于干预，因此需要对特别需要支持的目标群体以及适当的干预措施进行进一步研究。
