Pompidou A, Lang J M, Telvi L, Delsaux M C, Sarin P
Comp Immunol Microbiol Infect Dis. 1986;9(2-3):263-7. doi: 10.1016/0147-9571(86)90020-2.
Isoprinosine and Imuthiol are non mitogenic immunomodulators active on T cell differentiation. In ARC patients, they modulate the circulating T cell receptor complex in terms of OKT4+ phenotype induction. This effect is not responsible for any expansion of the target population but for a partial inhibition of in vitro infection with LAV/HTLV III viral particles. At a clinical level, this means that these drugs may prove helpful in ARC patients when the virus has infected only a few helper cells.
异丙肌苷和免疫硫醇是对T细胞分化有活性的非促有丝分裂免疫调节剂。在艾滋病相关综合征（ARC）患者中，它们在诱导OKT4 +表型方面调节循环T细胞受体复合物。这种作用并非导致靶细胞群体的任何扩增，而是部分抑制体外被淋巴结相关病毒/人嗜T淋巴细胞病毒III型（LAV/HTLV III）病毒颗粒感染。在临床层面，这意味着当病毒仅感染少数辅助细胞时，这些药物可能对ARC患者有帮助。
