Department of Pediatric Oncology and Hematology, Medical University of Bialystok, 15-274 Bialystok, Poland.
Int J Endocrinol. 2013;2013:805312. doi: 10.1155/2013/805312. Epub 2013 Nov 4.
Childhood cancer survivors are in augmented risk for developing obesity. For many factors leptin and leptin receptor gene polymorphism play an important role in the development and metabolism not only of fat, but also, bone tissue. The aim of the analysis was to find the relationships between Q223R, leptin levels, and anthropometric parameters. Patients and Methods. In the study 74 cancer survivors participated (ALL n = 64, lymphomas n = 10), and the control group consisted of 51 healthy peers. Leptin blood concentration was determined by ELISA method. To estimate leptin receptor gene polymorphism, RFLP method was used. Bone mineral density (BMD) and content (BMC), fat, and lean tissue measurements were obtained by DXA. Results. We found no correlations between serum leptin concentrations and anthropometric parameters nor BMD. Serum leptin concentrations were significantly lower in the group of cancer survivors compared to controls; however, in those overweight from examined group we found leptin levels higher than those in nonoverweight. Genotype Q223R was not associated with higher leptin levels, BMI, BMD, body fat or lean tissue. Conclusion. To our knowledge, this is the first report describing the relationship between BMD and Q223R polymorphism in childhood cancer survivors. Further analysis, based on a larger group of patients, is needed to confirm these findings.
儿童癌症幸存者发生肥胖的风险增加。许多因素中，瘦素和瘦素受体基因多态性在脂肪和骨组织的发育和代谢中发挥重要作用。本分析的目的是探讨 Q223R 与瘦素水平和人体测量参数之间的关系。
患者和方法。在这项研究中，共有 74 名癌症幸存者（ALL n=64，淋巴瘤 n=10）和 51 名健康同龄人参加。采用 ELISA 法测定血清瘦素浓度。采用 RFLP 法检测瘦素受体基因多态性。通过 DXA 测量骨矿物质密度（BMD）和含量（BMC）、脂肪和瘦组织。
结果。我们未发现血清瘦素浓度与人体测量参数或 BMD 之间存在相关性。与对照组相比，癌症幸存者组的血清瘦素浓度显著降低；然而，在超重的患者中，我们发现瘦素水平高于非超重患者。Q223R 基因型与较高的瘦素水平、BMI、BMD、体脂肪或瘦组织无关。
结论。据我们所知，这是第一项描述儿童癌症幸存者 BMD 与 Q223R 多态性之间关系的报告。需要进一步分析，以确认这些发现。
