Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Evid Based Complement Alternat Med. 2013;2013:567045. doi: 10.1155/2013/567045. Epub 2013 Nov 10.
Jiao Tai Wan (JTW), a Chinese herbal formula containing Rhizoma Coptidis and Cortex Cinnamomi, has been used for diabetic treatment for many years. The aim of this study was to determine the main components in JTW and to investigate the effects of JTW on hepatic lipid accumulation in diabetic rats and humans. JTW extract was prepared and the main components were assayed by HPLC. An animal model of diabetes mellitus was established and JTW was administered intragastrically. In the clinical study, diabetic patients with poor glycemic control were treated with JTW. Blood glucose and lipid parameters, liver histology, hepatic triglyceride content and lipogenic gene expression were examined. Our data demonstrated that JTW significantly improved hyperglycemia, hyperlipidemia and hepatic lipid accumulation in diabetic rats. This was accompanied by the down-regulation of acetyl coenzyme A carboxylase (ACC) and fatty acid synthase (FAS) protein expressions, and the up-regulation of AMP-activated protein kinase (AMPK) and phosphorylated-ACC (pACC) protein expressions in the liver tissues. Diabetic patients also exhibited decreases in their hepatic triglyceride content. The results suggest that JTW attenuates hepatic lipid accumulation in diabetic rats and humans. These beneficial effects are possibly associated with the inhibition of lipogenic gene expression in the liver.
交泰丸（JTW）是一种中药复方，由黄连和肉桂组成，多年来一直用于糖尿病的治疗。本研究旨在确定 JTW 的主要成分，并研究 JTW 对糖尿病大鼠和人类肝脏脂质积累的影响。JTW 提取物通过 HPLC 进行制备和主要成分分析。建立糖尿病动物模型，通过灌胃给予 JTW。在临床研究中，血糖控制不佳的糖尿病患者给予 JTW 治疗。检测血糖和血脂参数、肝组织学、肝组织三酰甘油含量和生脂基因表达。我们的数据表明，JTW 可显著改善糖尿病大鼠的高血糖、高血脂和肝脏脂质积累。这伴随着肝组织乙酰辅酶 A 羧化酶（ACC）和脂肪酸合酶（FAS）蛋白表达的下调，以及 AMP 激活的蛋白激酶（AMPK）和磷酸化-ACC（pACC）蛋白表达的上调。糖尿病患者的肝组织三酰甘油含量也降低。结果表明，JTW 可减轻糖尿病大鼠和人类的肝脏脂质积累。这些有益作用可能与抑制肝脏生脂基因表达有关。
