[法国肝细胞癌中乙肝病毒血清标志物与甲胎蛋白之间的关系]
[Relation between serum markers of hepatitis B virus and alpha fetoprotein in hepatocellular carcinoma in France].
作者信息
Attali P, Prod'homme S, Pelletier G, Papoz L, Buffet C, Etienne J P
出版信息
Gastroenterol Clin Biol. 1986 Oct;10(10):637-40.
Prevalences of serum markers of hepatitis B virus and alphafetoprotein levels were investigated in 96 patients with hepatocellular carcinoma. Serum HBs Ag was present in 17 patients (17.5 p. 100), anti-HBc antibody alone in 10 patients (10.5 p. 100), and anti-HBs antibody with or without associated anti-HBc antibody in 32 patients (33.5 p. 100). Serum alphafetoprotein levels were increased (greater than 20 ng/ml) in 71 patients (74 p. 100). Serum alphafetoprotein levels were significantly higher in patients with than in patients without serum HBs Ag. Serum alphafetoprotein levels above 1,000 ng/ml were more frequently found in patients with serum HBs Ag or anti-HBc antibody than in other patients. These results suggest the presence of a link between HBs Ag and alphafetoprotein in hepatocellular carcinoma.
对96例肝细胞癌患者的乙肝病毒血清标志物和甲胎蛋白水平的患病率进行了调查。17例患者（占17.5%）血清中存在乙肝表面抗原（HBs Ag），10例患者（占10.5%）仅存在乙肝核心抗体（anti-HBc），32例患者（占33.5%）存在乙肝表面抗体（anti-HBs），伴或不伴有乙肝核心抗体。71例患者（占74%）血清甲胎蛋白水平升高（大于20 ng/ml）。有血清HBs Ag的患者血清甲胎蛋白水平显著高于无血清HBs Ag的患者。血清HBs Ag或乙肝核心抗体阳性的患者中，血清甲胎蛋白水平高于1000 ng/ml的情况比其他患者更常见。这些结果表明，在肝细胞癌中，HBs Ag与甲胎蛋白之间存在联系。
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