Chien M C, Tong M J, Lo K J, Lee J K, Milich D R, Vyas G N, Murphy B L
J Natl Cancer Inst. 1981 Mar;66(3):475-9.
The presence of hepatitis B viral markers in patients with primary hepatocellular carcinoma (PHC) was studied retrospectively at the Taiwan Veterans General Hospital in Taipei, Taiwan. Serum samples from 102 PHC patients and from 100 control individuals were tested for hepatitis B surface antigen (HBsAg), antibody to HBsAg (anti-HBs), antibody to hepatitis B core antigen (anti-HBc), hepatitis Be antigen (HBeAg), and antibody to HBeAg (anti-HBe). Of the 102 PHC patients, 72 (71%) were positive for HBsAg. Nine (9%) additional patients were positive for anti-HBc alone in high titer, 19 (19%) had both anti-HBc and anti-HBs, and 9 (9%) had HBsAg, anti-HBc, and anti-HBs. In the 100 controls, 12 (12%) were HBsAg-positive, whereas 22 (22%) had anti-HBc alone and 50 (50%) had both anti-HBc and anti-HBs. Only 4 (4%) controls and no PHC patients had anti-HBs alone. Of the HBsAg-positive patients with PHC, 17 (29%) had HBeAg and 36 (61%) had anti-HBe. The alpha-fetoprotein (AFP) levels above 400 ng/ml were found in 44% of the PHC patients. Values of AFP above 1 x 10(5) ng/ml were more frequently detected in PHC patients who were HBsAg-positive. Categorization of the geographic origins of the families whose members had PHC revealed that most families had originated from southern China. This study confirms that hepatitis B viral markers are frequently present in Chinese patients with PHC.
台湾台北市荣民总医院对原发性肝细胞癌（PHC）患者体内乙肝病毒标志物的存在情况进行了回顾性研究。对102例PHC患者和100例对照个体的血清样本进行了乙肝表面抗原（HBsAg）、乙肝表面抗原抗体（抗-HBs）、乙肝核心抗原抗体（抗-HBc）、乙肝e抗原（HBeAg）和乙肝e抗原抗体（抗-HBe）检测。102例PHC患者中，72例（71%）HBsAg呈阳性。另外9例（9%）患者仅抗-HBc高滴度呈阳性，19例（19%）同时有抗-HBc和抗-HBs，9例（9%）有HBsAg、抗-HBc和抗-HBs。100例对照中，12例（12%）HBsAg呈阳性，22例（22%）仅抗-HBc呈阳性，50例（50%）同时有抗-HBc和抗-HBs。仅4例（4%）对照个体仅有抗-HBs，PHC患者中无此情况。在HBsAg呈阳性的PHC患者中，17例（29%）有HBeAg，36例（61%）有抗-HBe。44%的PHC患者甲胎蛋白（AFP）水平高于400 ng/ml。AFP值高于1×10⁵ ng/ml在HBsAg呈阳性的PHC患者中更常检测到。对家庭成员患有PHC的家庭的地理来源进行分类显示，大多数家庭来自中国南方。本研究证实，乙肝病毒标志物在中国PHC患者中经常出现。
