Mozhayeva G N, Naumov A P, Nosyreva E D
Gen Physiol Biophys. 1986 Apr;5(2):153-8.
Sodium channels in nodal membrane modified by a synthetic analog of batrachotoxin, 7,8-dihydrobatrachotoxinin A-20 alpha-benzoate, were studied under voltage clamp conditions. The voltage dependence of channel activation was shifted by 70-80 mV towards more negative potentials. Selectivity sequence determined from peak current reversal potential was as follows: Na:NH4:K = 1:0.46:0.23. Our data suggest that 7,8-dihydrobatrachotoxinin A-20 alpha-benzoate has qualitatively similar effects on the properties of sodium channels as does natural batrachotoxin.
在电压钳条件下，研究了由蟾毒素的合成类似物7,8 - 二氢蟾毒素A - 20α - 苯甲酸酯修饰的结膜中的钠通道。通道激活的电压依赖性向更负的电位偏移了70 - 80 mV。由峰值电流反转电位确定的选择性序列如下：Na:NH4:K = 1:0.46:0.23。我们的数据表明，7,8 - 二氢蟾毒素A - 20α - 苯甲酸酯对钠通道特性的影响在性质上与天然蟾毒素相似。
