Zubov A N, Naumov A P, Khodorov B I
Tsitologiia. 1984 Apr;26(4):415-23.
Currents through normal and batrachotoxin (BTX)-modified sodium channels of dialyzed neuroblastoma cells were measured under voltage clamp conditions. BTX is shown to induce a shift of voltage range of activation toward more negative potentials by 25-40 mV and the appearance of steady-state sodium conductance. BTX-modified sodium channels retain the ability to partial inactivation. It is evidenced by partial decay of the current during maintained depolarization and by dependence of current size and kinetics on prepulses. BTX induces changes in channel selectivity. Permeability ratios determined from reversal potential measurements are: Na : NH4 : K = 1 : 0.70 : 0.29 and 1 : 0.35 : 0.11 for BTX-modified and normal channels, respectively.
在电压钳制条件下，测量了透析神经母细胞瘤细胞正常和经蛙毒（BTX）修饰的钠通道中的电流。结果表明，BTX可使激活电压范围向更负电位方向偏移25 - 40 mV，并出现稳态钠电导。BTX修饰的钠通道保留了部分失活的能力。这可通过持续去极化期间电流的部分衰减以及电流大小和动力学对预脉冲的依赖性来证明。BTX会引起通道选择性的变化。根据反转电位测量确定的渗透率比分别为：BTX修饰通道的Na:NH4:K = 1:0.70:0.29，正常通道的为1:0.35:0.11。
