间充质多能基质细胞对阿尔茨海默型神经退行性变动物记忆的治疗作用。
Therapeutic effect of mesenchymal multipotent stromal cells on memory in animals with Alzheimer-type neurodegeneration.
作者信息
Bobkova N V, Poltavtseva R A, Samokhin A N, Sukhikh G T
机构信息
Institute of Cell Biophysics, Russian Academy of Science; V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health Care of the Russian Federation, Moscow, Russia.
出版信息
Bull Exp Biol Med. 2013 Nov;156(1):119-21. doi: 10.1007/s10517-013-2293-z.
Transplantation of human mesenchymal multipotent stromal cells improved spatial memory in bulbectomized mice with Alzheimer-type neurodegeneration. The positive effect was observed in 1 month after intracerebral transplantation and in 3 months after systemic injection of mesenchymal multipotent stromal cells. No cases of malignant transformation were noted. These findings indicate prospects of using mesenchymal multipotent stromal cells for the therapy of Alzheimer disease and the possibility of their systemic administration for attaining the therapeutic effect.
人骨髓间充质多能基质细胞移植改善了患有阿尔茨海默病型神经退行性变的去嗅球小鼠的空间记忆。在脑内移植后1个月和全身注射间充质多能基质细胞后3个月观察到了积极效果。未发现恶性转化病例。这些发现表明了使用间充质多能基质细胞治疗阿尔茨海默病的前景以及通过全身给药实现治疗效果的可能性。
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