多巴胺对出生后大鼠心脏发育过程中的变力作用。

Inotropic effect of dopamine on rat heart during postnatal ontogeny.

作者信息

Bilalova G A, Kazanchikova L M, Zefirov T L, Sitdikov F G

机构信息

Department of Anatomy, Physiology, and Human Health Care, Kazan Federal University, Kazan, Russia.

出版信息

Bull Exp Biol Med. 2013 Dec;156(2):173-6. doi: 10.1007/s10517-013-2303-1.

DOI:10.1007/s10517-013-2303-1

PMID:24319741

Abstract

We studied the effect of dopamine in concentrations of 10(-9), 10(-8), 10(-7), 10(-6), and 10(-5) M on contraction strength of isolated myocardial strips from the right atrium and right ventricle of rats aging 21, 42, 56, and 100 days. Dopamine in a concentration of 10(-9) M had a positive inotropic effect in rats of various ages. Increasing the concentration of dopamine to 10(-7)-10(-5) M was accompanied by a negative inotropic effect on the heart.

摘要

我们研究了浓度为10^(-9)、10^(-8)、10^(-7)、10^(-6)和10^(-5)M的多巴胺对21、42、56和100日龄大鼠右心房和右心室离体心肌条收缩强度的影响。浓度为10^(-9)M的多巴胺对各年龄段大鼠均有正性肌力作用。将多巴胺浓度增至10^(-7)-10^(-5)M时，心脏出现负性肌力作用。