个体发育过程中大鼠心肌收缩性多巴胺能调节中的肾上腺素能受体
Adrenoceptors in Dopaminergic Regulation of Rat Myocardial Contractility in Rats During Ontogeny.
作者信息
Bilalova G A, Sitdikov F G, Dikopol'skaya N B, Shaikhelislamova M V, Zefirov T L
机构信息
Department of Human Health Protection, Kazan (Volga Region) Federal University, Kazan, Russia.
出版信息
Bull Exp Biol Med. 2017 Apr;162(6):769-772. doi: 10.1007/s10517-017-3709-y. Epub 2017 Apr 20.
The effects of different dopamine concentrations on contractility of myocardium with blocked α- or β-adrenoceptors were examined in vitro in 21- and 100-day old rats. In myocardial strips with blocked α-adrenoceptors, dopamine (10 M) increased the right atrial contractile force. By contrast, this neurotransmitter (10-10 M) reduced the contractile force of atrial and ventricular strips with blocked β-adrenoceptors.
在21日龄和100日龄大鼠中，体外研究了不同多巴胺浓度对α或β肾上腺素能受体阻断的心肌收缩性的影响。在α肾上腺素能受体阻断的心肌条中，多巴胺（10μM）增加右心房收缩力。相比之下，这种神经递质（10⁻¹⁰M）降低了β肾上腺素能受体阻断的心房和心室条的收缩力。
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