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[用凝血酶抑制剂稳定供血]

[Stabilization of donor blood with thrombin inhibitors].

作者信息

Drawert J, Stein P

出版信息

Folia Haematol Int Mag Klin Morphol Blutforsch. 1986;113(4):560-5.

PMID:2431979
Abstract

The content of free calcium ions in stored blood can be maintained by stabilizing it with thrombin inhibitors. With regard to a long-term stabilization of blood or blood plasma, satisfactory results can only be achieved with the competitive synthetic thrombin inhibitor 4-amidinophenylpyruvic acid by adding slight amounts of heparin and by storing it in a cool room. By using hirudin (greater than 50 ATE/ml of blood) the stabilization of blood enables a long-lasting anticoagulative effect to be achieved, such as it is required for the purpose of reprocessing blood to plasma fractions.

摘要

储存血液中游离钙离子的含量可通过用凝血酶抑制剂使其稳定来维持。关于血液或血浆的长期稳定,只有通过添加少量肝素并将其储存在凉爽的房间里,使用竞争性合成凝血酶抑制剂4-脒基苯基丙酮酸才能取得满意的结果。通过使用水蛭素(每毫升血液大于50抗凝血酶单位)来稳定血液,能够实现持久的抗凝效果,这是将血液再加工成血浆成分所需要的。

相似文献

1
[Stabilization of donor blood with thrombin inhibitors].[用凝血酶抑制剂稳定供血]
Folia Haematol Int Mag Klin Morphol Blutforsch. 1986;113(4):560-5.
2
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Thrombin generation and clot formation in methylene blue-treated plasma and cryoprecipitate.亚甲蓝处理的血浆和冷沉淀中的凝血酶生成及凝块形成。
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