[亚洲狂犬病病毒的进化与传播特征]
[Evolutionary and transmission characteristics of rabies viruses in Asia].
作者信息
Tao Xiao-Yan, Li Hao, Tang Qing, Liang Guo-Dong
机构信息
Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, China CDC, Beijing.
出版信息
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2013 Jun;27(3):187-9.
OBJECTIVE
To understand the rabies virus (RABV) evolutionary relationship between the strains of China and Asia and to know the evolution and transmission characteristics of RABV in Asia.
METHODS
The G sequences of representative strains from China were selected and combined the sequences of other countries in Asia to analyze using BEAST and MigraPhyla software.
RESULTS
The phylogenetic analysis showed that six groups (China I-VI) of China had different epidemic range: China I , II and V groups just cycled in our country; China VI group, from Guangxi and Yunnan provinces, crossed with Southeast Asian strains; China III group and IV group also have closer genetic relationship with Asian country strains.
CONCLUSION
Geographic migration in Asia showed that Thailand and India may be two rabies transmission centers in Asia.
目的
了解中国与亚洲其他地区狂犬病病毒（RABV）毒株之间的进化关系，明确RABV在亚洲的进化及传播特征。
方法
选取中国代表性毒株的G基因序列，并结合亚洲其他国家的序列，运用BEAST和MigraPhyla软件进行分析。
结果
系统发育分析显示，中国的六个组（中国I - VI组）具有不同的流行范围：中国I、II和V组仅在我国循环；来自广西和云南省的中国VI组与东南亚毒株交叉；中国III组和IV组也与亚洲国家毒株有更密切的遗传关系。
结论
亚洲的地理迁移表明，泰国和印度可能是亚洲的两个狂犬病传播中心。
Zotero 插件