Institute of Zoonoses, Jilin University, Changchun 130062, China.
Virus Res. 2010 Jun;150(1-2):111-8. doi: 10.1016/j.virusres.2010.02.019. Epub 2010 Mar 7.
Phylogenetic studies have revealed a profound understanding about the biodiversity of rabies viruses in China, but little is known about their evolutionary dynamics in the country. In the present study, the complete G gene sequences of 33 rabies virus isolates (RABVs) isolated from distinct Chinese provinces were determined and phylogenetic analysis was conducted using these G sequences and 93 others retrieved from GenBank representing China and Southeast Asia. Further evolutionary history of RABV was estimated using a Bayesian Markov chain Monte Carlo method to understand the temporal and spatial dynamics of this virus. Results showed that rabies viruses in China and Southeast Asia share a common ancestor and form 2 clades with each being further divided into 3 lineages. The time of the most recent common ancestor of current RABV strains was estimated to be year 1654 (1514-1812) and the viruses circulating in Southeast Asia likely derived from China.
系统发育研究揭示了中国狂犬病病毒多样性的深刻认识，但对其在中国的进化动态知之甚少。本研究测定了 33 株分离自中国不同省份的狂犬病病毒（RABV）的完整 G 基因序列，并对这些 G 序列和从代表中国和东南亚的 GenBank 中检索到的 93 个其他序列进行了系统发育分析。使用贝叶斯马尔可夫链蒙特卡罗方法估计 RABV 的进化历史，以了解该病毒的时空动态。结果表明，中国和东南亚的狂犬病病毒有一个共同的祖先，并形成 2 个分支，每个分支进一步分为 3 个谱系。目前 RABV 株的最近共同祖先时间估计为 1654 年（1514-1812 年），东南亚流行的病毒可能起源于中国。
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