Department of Pharmacology and Clinical Neuroscience, Section of Neurology, Umeå University, SE-90187, Umeå, Sweden.
Expert Rev Neurother. 2014 Jan;14(1):9-18. doi: 10.1586/14737175.2014.864952. Epub 2013 Dec 9.
This article briefly introduces the basics of multiple sclerosis' (MS) clinical hallmarks and pathophysiology. Vitamin D is presented, including its metabolism and effects on the immune system. The epidemiological observations linking vitamin D to MS range from a half century old findings of latitude gradients and migrational risk patterns to modern, nested, case-control biobank studies. These observations show an association without doubt although causation has yet to be proven. Vitamin D as a treatment for MS is an emerging concept and both current and anticipated data will be covered. Lastly, we discuss future challenges, ideas on how to move from association to causation, and the prospect of primary prevention of this disabling disease.
本文简要介绍多发性硬化症 (MS) 的临床特征和病理生理学基础知识。介绍了维生素 D，包括其代谢和对免疫系统的影响。将维生素 D 与 MS 相关联的流行病学观察结果可以追溯到半个世纪前的纬度梯度和移民风险模式的发现，以及现代的巢式病例对照生物库研究。这些观察结果无疑表明存在关联，但因果关系尚未得到证实。维生素 D 作为 MS 的一种治疗方法是一个新兴概念，本文将涵盖当前和预期的数据。最后，我们讨论了未来的挑战、从关联到因果关系的思路，以及预防这种致残疾病的前景。
