Niino Masaaki, Miyazaki Yusei
Department of Clinical Research, Hokkaido Medical Center.
Brain Nerve. 2015 Nov;67(11):1429-33. doi: 10.11477/mf.1416200316.
The geographic epidemiology of multiple sclerosis (MS) suggests that low vitamin D levels are a modifiable risk factor. Previous studies have shown that patients with MS have significantly lower vitamin D levels compared with healthy controls. Vitamin D is a potent immunomodulator important for immune function and development, and it offers potential benefits by reducing inflammation. Vitamin D has beneficial effects in experimental autoimmune encephalomyelitis, an animal model of MS. In summation, these studies suggest that vitamin D may have therapeutic potential for MS. This has not been established although preliminary clinical trials for vitamin D in MS look promising. Genetic studies suggest that genes associated with vitamin D are critical susceptible genes for MS. In this review, we discuss current research investigating the association between vitamin D and MS and the issues that need to be resolved.
多发性硬化症（MS）的地理流行病学表明，低维生素D水平是一个可改变的风险因素。先前的研究表明，与健康对照相比，MS患者的维生素D水平显著更低。维生素D是一种对免疫功能和发育很重要的强效免疫调节剂，它通过减轻炎症发挥潜在益处。维生素D在实验性自身免疫性脑脊髓炎（一种MS的动物模型）中具有有益作用。总之，这些研究表明维生素D可能对MS具有治疗潜力。尽管MS中维生素D的初步临床试验看起来很有前景，但这一点尚未得到证实。基因研究表明，与维生素D相关的基因是MS的关键易感基因。在这篇综述中，我们讨论了目前关于维生素D与MS之间关联的研究以及需要解决的问题。
