口腔DNA人乳头瘤病毒与生殖器DNA人乳头瘤病毒之间的关联。
Association between oral DNA-HPV and genital DNA-HPV.
作者信息
Vidotti Lisandra Rocha, Vidal Flávia Castello Branco, Monteiro Sally Cristina Moutinho, Nunes Jomar Diogo, Salgado João Victor, Brito Luciane Maria Oliveira, Lopes Fernanda Ferreira
机构信息
Post-Graduation Program for Maternal Child Health, Federal University of Maranhão (UFMA), São Luis, Brazil.
出版信息
J Oral Pathol Med. 2014 Apr;43(4):289-92. doi: 10.1111/jop.12141. Epub 2013 Dec 10.
BACKGROUND
Human papillomavirus (HPV) infection is one of the most common sexually transmitted diseases worldwide and is observed in both men and women. The presence of the virus is often associated with benign and malignant neoplasms of the oral cavity. We wished to investigate whether HPV infection in the genitalia was associated with HPV infection in the oral mucosa.
METHODS
The prevalence of HPV in the oral cavity and genitalia was evaluated by DNA extraction from genital and oral cavity samples of 105 women, followed by nested PCR.
RESULTS AND CONCLUSIONS
The prevalence of HPV in the oral cavity was significantly higher in women who had genital HPV (P < 0.0001). Oral sex, alcohol, and tobacco consumption were not associated with the oral HPV infection.
背景
人乳头瘤病毒（HPV）感染是全球最常见的性传播疾病之一，在男性和女性中均有发现。该病毒的存在常与口腔的良性和恶性肿瘤相关。我们希望研究生殖器HPV感染是否与口腔黏膜HPV感染有关。
方法
通过从105名女性的生殖器和口腔样本中提取DNA，随后进行巢式聚合酶链反应，评估口腔和生殖器中HPV的患病率。
结果与结论
生殖器感染HPV的女性口腔中HPV患病率显著更高（P < 0.0001）。口交、饮酒和吸烟与口腔HPV感染无关。
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