Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, People's Republic of China.
Department of Otorhinolaryngology, Head and Neck Surgery, The Chinese University of Hong Kong, People's Republic of China.
J Infect Dis. 2018 Jul 2;218(3):388-397. doi: 10.1093/infdis/jiy160.
Knowledge of the prevalence of and risk factors for oral human papillomavirus (HPV) infection, especially cutaneous types, is limited.
A population-based study using next-generation sequencing consecutively recruited asymptomatic individuals aged 18-64 years from a proportional sampling of the general population of Hong Kong, according to age groups, gender, and regions of residence. We examined associations of alpha-, beta-, and gamma-HPVs from oral rinse samples with participants' sociodemographics by logistic regression models.
The prevalence of oral HPV infection among 1426 ethnic Chinese was 15.5% (95% confidence interval [CI], 13.7%-17.5%), 2.5% (95% CI, 1.8%-3.5%), 11.9% (95% CI, 10.3%-13.6%), and 2.9% (95% CI, 2.1%-3.9%) for any type, alpha-, beta-, and gamma-HPV, respectively. Prevalence of any high-risk HPV was 0.8% (95% CI, 0.4%-1.4%), and that of HPV-16 was 0.4% (95% CI, 0.2%-0.8%). HPV-8 and HPV-98 were the most common beta types detected, while HPV-4 and HPV-SD2R were the most common gamma types. Prevalence of alpha- and beta/gamma-HPV infection showed a similar pattern of increase with age, and was higher in men than women. Smoking, drinking, oral sex, and more sexual partners were associated with alpha-HPV. Teeth brushing before sleep was protective for beta/gamma-HPVs.
The epidemiologic factors associated with oral infection with alpha-HPVs are different from those of beta/gamma-HPVs, suggesting different modes of acquisition and persistence.
人们对口腔人乳头瘤病毒（HPV）感染，尤其是皮肤型 HPV 的流行情况和危险因素知之甚少。
采用基于人群的研究，使用下一代测序技术，连续招募来自香港普通人群的按年龄组、性别和居住地区比例抽样的 18-64 岁无症状个体。我们通过逻辑回归模型，分析了口腔冲洗样本中α-、β-和γ-HPV 与参与者社会人口统计学特征之间的关联。
1426 名华裔个体的口腔 HPV 感染总流行率为 15.5%（95%置信区间[CI]，13.7%-17.5%）、2.5%（95%CI，1.8%-3.5%）、11.9%（95%CI，10.3%-13.6%）和 2.9%（95%CI，2.1%-3.9%），分别对应任何类型、α-、β-和γ-HPV。任何高危 HPV 的流行率为 0.8%（95%CI，0.4%-1.4%），HPV-16 的流行率为 0.4%（95%CI，0.2%-0.8%）。检测到的最常见β型 HPV 为 HPV-8 和 HPV-98，最常见γ型 HPV 为 HPV-4 和 HPV-SD2R。α-和β/γ-HPV 感染的流行率呈相似的随年龄增长而增加的模式，且男性高于女性。吸烟、饮酒、口交和更多性伴侣与α-HPV 相关。睡前刷牙对β/γ-HPV 具有保护作用。
与β/γ-HPV 感染相关的口腔感染的流行病学因素与α-HPV 不同，提示其传播和持续存在的模式不同。
