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国家脊髓灰质炎病毒实验室在根除脊髓灰质炎计划及脊髓灰质炎监测中的作用

[Role of the National Poliovirus Laboratory for the Program of eradication and poliomyelitis surveillance].

作者信息

Trallero Gloria, Cabrerizo María, Avellón Ana

机构信息

Laboratorio Nacional de Poliovirus, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, España.

出版信息

Rev Esp Salud Publica. 2013 Sep-Oct;87(5):471-9. doi: 10.4321/S1135-57272013000500006.

Abstract

The Spanish acute flaccid paralysis surveillance network is coordinated by the National Poliovirus Laboratory (NPL), which, since 1998, carries out polioviruses (PV) and other enteroviruses detected characterization by cell culture and molecular techniques. A total of 110,725 (70046+40679) samples were studied between 1998-2012 and enteroviruses were detected in 8% of these. Among these enteroviruses 241 PV were characterized as PV Sabin-like, except samples belong to an imported poliomyelitis case, all of which were characterised as vaccine derived PV type 2. The NPL has carried out the serotyping and the intratypic differentiation of all the isolated PV in Spain of any syndrome. It is shown that wild PV has not circulated in our country during the 15 years studied and that has led to the signing of the Act of the "eradication of poliomyelitis in Spain" by WHO in 2001, and the /"certification of the eradication of wild PV free for European countries" on 21 June 2002. Currently only 3 countries have endemic transmission of wild PV (Pakistan, Afghanistan and Nigeria). Until a complete worldwide eradication, was achieved, Spain will actively continue to participate in the maintenance of the poliomyelitis eradication infrastructure by monitoring and vaccination as well as the wild PV containment plan to avoid the spread of wild PV.

摘要

西班牙急性弛缓性麻痹监测网络由国家脊髓灰质炎病毒实验室(NPL)协调,该实验室自1998年以来一直通过细胞培养和分子技术对检测到的脊髓灰质炎病毒(PV)和其他肠道病毒进行特征分析。1998年至2012年期间共研究了110725份(70046 + 40679)样本,其中8%检测出肠道病毒。在这些肠道病毒中,241株PV被鉴定为类似Sabin株的PV,除了属于输入性脊髓灰质炎病例的样本外,所有样本均被鉴定为疫苗衍生2型PV。NPL对西班牙所有分离出的PV进行了血清型鉴定和型内分化,无论其综合征如何。结果表明,在所研究的15年中,我国未发现野生PV传播,这促使世界卫生组织于2001年签署了“西班牙根除脊髓灰质炎法案”,并于2002年6月21日颁发了“欧洲国家野生PV根除认证”。目前仅有3个国家存在野生PV的地方性传播(巴基斯坦、阿富汗和尼日利亚)。在全球彻底根除脊髓灰质炎之前,西班牙将继续积极参与维持脊髓灰质炎根除基础设施,包括监测、疫苗接种以及野生PV遏制计划,以避免野生PV传播。

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