From the *College of Public Health and Nutrition, Taipei Medical University; and †Vita Genomics, Inc, Taipei; and ‡Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan.
J Investig Med. 2014 Feb;62(2):310-5. doi: 10.2310/JIM.0000000000000030.
The single-nucleotide polymorphism (SNP), rs1042714 or glutamine 27 glutamic acid (Gln27Glu), in the adrenoceptor β2 surface (ADRB2) gene has previously been examined for association with obesity with inconclusive results. The objective of this study was to determine whether the ADRB2 rs1042714 SNP could influence obesity and obesity-related metabolic traits in a Taiwanese population.
The ADRB2 rs1042714 SNP and obesity-related metabolic traits including blood pressure, total cholesterol, triglyceride, fasting glucose, waist circumference, and body mass index (BMI) were examined in 967 individuals with general health examinations.
Our data revealed that the ADRB2 rs1042714 SNP exhibited a significant association with obesity among the subjects (P = 0.021). Furthermore, the carriers of the GG genotype had a significantly higher BMI than those with the CC genotype (26.0 ± 5.6 vs 24.3 ± 3.8 kg/m; P = 0.009) and those with the CG genotype (26.0 ± 5.6 vs 23.6 ± 3.3 kg/m; P = 0.001). We also found a nominal association with systolic blood pressure (P = 0.058) and triglyceride (P = 0.055) levels in the ADRB2 rs1042714 SNP.
Our study indicates that the ADRB2 rs1042714 SNP may contribute to the risk of obesity and predict obesity-related metabolic traits such as BMI, triglyceride, and systolic blood pressure in Taiwanese subjects.
肾上腺素能受体β2 表面（ADRB2）基因中的单核苷酸多态性（SNP）rs1042714 或谷氨酰胺 27 谷氨酸（Gln27Glu）先前曾被研究与肥胖相关，但结果不一致。本研究的目的是确定 ADRB2 rs1042714 SNP 是否会影响台湾人群的肥胖和肥胖相关代谢特征。
在 967 名接受常规体检的个体中，检查了 ADRB2 rs1042714 SNP 与肥胖相关的代谢特征，包括血压、总胆固醇、甘油三酯、空腹血糖、腰围和体重指数（BMI）。
我们的数据显示，ADRB2 rs1042714 SNP 与受试者的肥胖显著相关（P = 0.021）。此外，GG 基因型携带者的 BMI 明显高于 CC 基因型携带者（26.0 ± 5.6 与 24.3 ± 3.8 kg/m；P = 0.009）和 CG 基因型携带者（26.0 ± 5.6 与 23.6 ± 3.3 kg/m；P = 0.001）。我们还发现 ADRB2 rs1042714 SNP 与收缩压（P = 0.058）和甘油三酯（P = 0.055）水平呈名义相关。
我们的研究表明，ADRB2 rs1042714 SNP 可能导致肥胖风险增加，并可预测台湾人群的 BMI、甘油三酯和收缩压等肥胖相关代谢特征。
