Sugai S, Takiguchi T, Hirose Y, Shimizu S, Imaoka S, Tachibana J, Sawada M, Konda S
Jpn J Clin Oncol. 1986 Dec;16(4):365-72.
A small amount of monoclonal IgM was demonstrated in the serum of four B cell malignant lymphoma patients in whom electrophoretically homogeneous protein bands were not detected by either cellulose acetate membrane electrophoresis or immunoelectrophoresis. By using anti-idiotypic (Id) antisera prepared against serum IgM, the M proteins were detected and identified as the products of malignant cells. These findings suggest that the use of more sensitive technics than the usual serum electrophoresis shows that the incidence of M proteins in B cell malignant lymphomas is higher than has been previously reported.
在4例B细胞恶性淋巴瘤患者的血清中检测到少量单克隆IgM，而醋酸纤维素膜电泳或免疫电泳均未检测到电泳均一的蛋白条带。通过使用针对血清IgM制备的抗独特型（Id）抗血清，检测并鉴定出M蛋白为恶性细胞的产物。这些发现表明，使用比常规血清电泳更敏感的技术显示，B细胞恶性淋巴瘤中M蛋白的发生率高于先前报道。
