Zhang Bin, Cao Xu, Liu Fei, Liu Xin, Wang Xin, Bai Jing
Department of Biomedical Engineering, Tsinghua University, Beijing, China.
Appl Opt. 2011 Oct 1;50(28):5397-407. doi: 10.1364/AO.50.005397.
In this study, we investigate the performance of early-photon fluorescence tomography based on a heterogeneous mouse model. The telegraph equation is used to accurately describe the propagation of light in tissues at short times. The optimal time gate for early photons is determined by singular value analysis at first. Then, fluorescent targets located in different organs of the mouse model are investigated. The simulation results demonstrate that the reconstructed tomographic images based on early photons yield improvement in spatial resolution and quantification than the quasi-CW measurements. Meanwhile, compared with the homogeneous model, the use of the heterogeneous model can improve the accuracy of fluorescence distribution and quantification in early-photon fluorescence tomography.
在本研究中，我们基于异质小鼠模型研究了早期光子荧光断层扫描的性能。电报方程用于精确描述短时间内光在组织中的传播。首先通过奇异值分析确定早期光子的最佳时间门。然后，研究了位于小鼠模型不同器官中的荧光靶点。模拟结果表明，基于早期光子重建的断层图像在空间分辨率和定量方面比准连续波测量有改进。同时，与均匀模型相比，使用异质模型可以提高早期光子荧光断层扫描中荧光分布和定量的准确性。
