手性布朗斯台德酸催化的吲哚与亚胺的对映选择性加成反应。
Chiral Brønsted acid-catalyzed enantioselective addition of indoles to ketimines.
机构信息
Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.
出版信息
Org Biomol Chem. 2014 Feb 7;12(5):724-7. doi: 10.1039/c3ob42190b. Epub 2013 Dec 10.
PMID:24323293
Abstract
A highly enantioselective addition of indoles to a readily available ketimine was found to be catalyzed by a chiral phosphoric acid. This organocatalytic process represents a rare example of an addition reaction to a non-aromatic ketimine.
摘要
一种手性磷酸可以高对映选择性地催化吲哚与易得的亚胺加成。该有机催化过程代表了非芳香族亚胺加成反应的罕见实例。
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