Laboratory of Neural Stem Cell Biology and Therapy, Lund Stem Cell Center, Lund University Hospital, SE-221 84, Lund, Sweden,
Transl Stroke Res. 2011 Sep;2(3):272-8. doi: 10.1007/s12975-011-0100-6. Epub 2011 Aug 11.
Stem cell-based approaches for the treatment of stroke have been the subject of intensive research over the past decade. Based on accumulated experimental evidence, stem cell-based therapy is a very promising prospect for the development of a novel treatment to restore stroke-damaged brain and impaired neurological function. Studies performed on experimental animal models of stroke employed a variety of stem cell types from diverse sources and have demonstrated their ability to replace lost neurons and functionally integrate into the brain, modulate inflammation, and stimulate angiogenesis and neurogenesis from an endogenous stem cell pool, most likely through trophic actions. A few clinical trials in stroke patients using stem cell transplantation have been completed or are on-going but the results have not yet proven the effectiveness of the stem cell-based approaches. A joint effort of stroke researchers and clinicians is needed to further optimize treatment protocols using safe and reproducible stem cell sources tested in relevant animal models of stroke and showing substantial neurological recovery of stroke-impaired function.
在过去的十年中，基于干细胞的中风治疗方法一直是密集研究的主题。基于积累的实验证据，干细胞疗法为开发一种新的治疗方法以恢复中风损伤的大脑和受损的神经功能提供了非常有希望的前景。在中风的实验动物模型上进行的研究采用了来自不同来源的各种干细胞类型，并证明了它们能够替代丢失的神经元并与大脑功能整合，调节炎症，并刺激内源性干细胞池的血管生成和神经发生，这可能是通过营养作用。已经完成了一些使用干细胞移植治疗中风患者的临床试验，或者正在进行中，但结果尚未证明基于干细胞的方法的有效性。需要中风研究人员和临床医生共同努力，进一步优化使用经过相关中风动物模型测试的安全且可重复的干细胞来源的治疗方案，并显示出中风受损功能的实质性神经恢复。
