Wada Kosuke, Makino Hiroshi, Shimada Kenji, Shikata Fumiaki, Kuwabara Atsushi, Hashimoto Tomoki
Department of Anesthesia and Perioperative Care, University of California, San Francisco, 1001 Potrero Avenue, No. 3C-38, San Francisco, CA, 94110, USA.
Transl Stroke Res. 2014 Apr;5(2):248-51. doi: 10.1007/s12975-013-0296-8. Epub 2013 Nov 6.
We have developed a mouse model of intracranial aneurysm that recapitulates key features of human intracranial aneurysms. In this model, spontaneous aneurysmal rupture occurs with a predictable time course. Aneurysmal rupture in this model can be easily detected by assessing neurological symptoms. Similar to human intracranial aneurysms, intracranial aneurysms in this model show an infiltration with inflammatory cells. This mouse model can be used to study the mechanisms and the potential preventive treatments for aneurysmal rupture.
我们已经开发出一种颅内动脉瘤小鼠模型，该模型概括了人类颅内动脉瘤的关键特征。在这个模型中，自发性动脉瘤破裂会按照可预测的时间进程发生。通过评估神经症状，可以很容易地检测到该模型中的动脉瘤破裂。与人类颅内动脉瘤相似，这个模型中的颅内动脉瘤表现出炎症细胞浸润。这个小鼠模型可用于研究动脉瘤破裂的机制和潜在的预防性治疗方法。
